Integrating Structure, Bioinformatics, and Enzymology to Discover Function
نویسندگان
چکیده
منابع مشابه
Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli.
Structural proteomics projects are generating three-dimensional structures of novel, uncharacterized proteins at an increasing rate. However, structure alone is often insufficient to deduce the specific biochemical function of a protein. Here we determined the function for a protein using a strategy that integrates structural and bioinformatics data with parallel experimental screening for enzy...
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The main objective of an ecosystem sustainable management is to preserve itscapacity to respond and adapt to current disturbances and/or future changes, and maintain theprovision of environmental goods and services. Two very important properties linked to thisobjective are the ecosystem resilience and resistance to disturbance factors. The objective ofthis paper is to recommend conceptual modif...
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the main objective of an ecosystem sustainable management is to preserve itscapacity to respond and adapt to current disturbances and/or future changes, and maintain theprovision of environmental goods and services. two very important properties linked to thisobjective are the ecosystem resilience and resistance to disturbance factors. the objective ofthis paper is to recommend conceptual modif...
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Proteins are the molecules of life which are involved in cellular processes. The functional specificity of a protein is linked to its structure. A great section of bioinformatics deals with the prediction, analysis and visualization of protein 3D structures. High-throughput methods for the determination of protein structures provide the information needed to build structure-activity relationshi...
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The exponentially increasing number of protein and nucleic acid sequences provides opportunities to discover novel enzymes, metabolic pathways, and metabolites/natural products, thereby adding to our knowledge of biochemistry and biology. The challenge has evolved from generating sequence information to mining the databases to integrating and leveraging the available information, i.e., the avai...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m303867200